Tip-spray ionization mass spectrometry for diagnosis of esophageal cancer: An analysis of 22 cases
نویسندگان
چکیده
منابع مشابه
Electrostatic-spray ionization mass spectrometry.
An electrostatic-spray ionization (ESTASI) method has been used for mass spectrometry (MS) analysis of samples deposited in or on an insulating substrate. The ionization is induced by a capacitive coupling between an electrode and the sample. In practice, a metallic electrode is placed close to but not in direct contact with the sample. Upon application of a high voltage pulse to the electrode,...
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Imaging samples on a surface by mass spectrometry (MS) requires the combination of MS detection with a scanning mode that enables localized desorption and ionization and/or detection of sample analytes with good spatial resolution. We have developed a new mass spectrometry imaging (MSI) method based on electrostatic spray ionization. It works under ambient conditions and can be applied to a wid...
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Kerian, Kevin S. Ph.D., Purdue University, May 2015. Molecular Diagnosis of Cancer using Ambient Ionization Mass Spectrometry. Major Professor: R. Graham Cooks. My dissertation focuses on advancing the development and application of ambient ionization mass spectrometry methodology and technology to the biomedical field. The primary ambient ionization method used in my studies is desorption elec...
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In this paper, we describe a novel technique--ultrasonication-assisted spray ionization (UASI)--for the generation of singly charged and multiply charged gas-phase ions of biomolecules (e.g., amino acids, peptides, and proteins) from solution; this method employs a low-frequency ultrasonicator (ca. 40 kHz) in place of the high electric field required for electrospray ionization. When a capillar...
متن کاملEasy ambient sonic-spray ionization-membrane interface mass spectrometry for direct analysis of solution constituents.
Using a cellulose dialysis membrane and aqueous solutions of common drugs as a proof-of-principle example, we demonstrate that solid but permeable and flexible membranes can be used as interfaces for the direct analysis of solution constituents via easy ambient sonic-spray ionization mass spectrometry. This new combination of MS techniques, herein termed EASI-MIMS, promotes droplet pick up of t...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2013
ISSN: 2219-2859
DOI: 10.11569/wcjd.v21.i23.2320